Mody Diabetes

The treatment for MODY is specific to the genetic subtype.  

Some types may be managed with diet, while others require oral medications (like sulfonylureas) or, in some cases, insulin.  

There are several types of MODY, each caused by a different gene mutation with its own characteristics and treatment.  

• HNF1A-MODY (MODY3) - the most common type. It causes a progressive decline in insulin production and is often initially misdiagnosed as Type 1 diabetes. It is very sensitive to low-dose sulfonylurea tablets, which help the body produce more insulin. 
• GCK-MODY (MODY2) - a milder form of diabetes with slightly elevated but stable blood sugar levels from birth. It is often asymptomatic and may not require medication, just careful monitoring. 
• HNF4A-MODY (MODY1) - like HNF1A-MODY and responsive to sulfonylureas. This type can be associated with a high birth weight and low blood sugar in newborns.  
• HNF1B-MODY (MODY5) - Often called Renal Cysts and Diabetes (RCAD) syndrome, this type is associated with kidney abnormalities and may require insulin treatment. 

• Monitor Blood Sugar - check your blood glucose levels to identify patterns and address any high or low readings that may be causing tiredness.  
• Stay Hydrated - drink plenty of water to prevent dehydration.  
• Eat a Balanced Diet - focus on whole foods, lean proteins, and fibre-rich vegetables to avoid blood sugar spikes and crashes.  
• Exercise Regularly - physical activity helps regulate blood sugar, improves mood, and can boost energy levels.  
• Prioritising Mental Health - manage stress and seek support from mental health professionals or support groups to alleviate anxiety and depression that can worsen fatigue.  
• Sleep Routine - aim for 7–9 hours of sleep per night with consistent bedtimes to combat sleep deprivation and improve insulin resistance.  

If fatigue is persistent, particularly if accompanied by excessive thirst or blurred vision, please visit your GP.